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This test is also an ELISA Antibodies test and is generally performed to detect either a Recent or a Remote exposure to the Herpes-1 and/or Herpes-2 viruses. Herpes IgM antibodies are the first to appear within a few days from exposure to the virus, reach a peak level within 2-4 weeks and slowly disappear within two-three months. IgM Antibodies are not type specific but they always indicate an heightened immunologic activity in response to antigenic challenge. They may be increased during a reactivation of an old Herpes infection and/or in the presence of antigenic material similar to Herpes, such in the case of CMV, Mono and Chicken Pox viruses, a situation is called "cross-reactivity". IgG antibodies type specific may appear within 3-4 weeks and are definitely present four months after exposure. They remain present indefinitely as immunological memory of a past infection. Therefore the exposure date is the time zero or starting point where to start orienting oneself in the understanding of Herpes Serological dynamics. 80% of people who tested positive to either Herpes 1 or 2 antibodies were unaware of the infection. If the exposure date is not known a screening test for both the IgM and IgG antibodies is appropriate. The testing time can than be used as a starting point in the Herpes testing.
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