Rapid (R)
plasma(P) reagin (R), is a blood test for
syphilis that looks for an antibody that is present in the bloodstream when
a patient has syphilis.
A negative (nonreactive)
RPR is compatible with a person not having syphilis, but in the early stages
of the disease, the RPR often gives false negative results. Conversely, a
false positive RPR can be encountered in infectious mononucleosis, lupus,
antiphospholipid antibody syndrome, hepatitis A, leprosy, malaria and,
occasionally, pregnancy
many of the signs and
symptoms are indistinguishable from those of other diseases.
always treatable but
curable only if diagnosed early
sores also can occur on
the lips and in the mouth.
if adequate treatment is
not administered, the infection progresses to the secondary stage.
approximately 30,000 cases of syphilis in adults are reported each year in
the United States.
the
risk of transmission to the fetus in untreated primary or secondary syphilis
is approximately 100%.
treatment is usually
100% effective and results in a cure with simple antibiotics from your
neighborhood doctor.
What is syphilis?
Syphilis is a complex
sexually transmitted disease (STD) caused by the bacterium
Treponema pallidum. It has often been called "the great imitator"
because so many of the signs and symptoms are indistinguishable from those
of other diseases.
How is syphilis
spread?
Syphilis is passed from
person to person through direct contact with a syphilis sore. Sores occur
mainly on the external genitals, vagina, anus, or in the rectum. Sores also
can occur on the lips and in the mouth. Transmission of the organism occurs
during vaginal, anal, or oral sex. Pregnant women with the disease can pass
it to the babies they are carrying. Syphilis cannot
be spread by toilet seats, door knobs, swimming pools, hot tubs, bath tubs,
shared clothing, or eating utensils.
Signs and symptoms in adults?
Primary Stage
The time between infection with syphilis and the start of the first
symptom can range from 10-90 days (average 21 days). The primary stage
of syphilis is usually marked by the appearance of a single sore (called
a chancre), but there may be multiple sores. The chancre is usually
firm, round, small, and painless. It appears at the spot where syphilis
entered the body. The chancre lasts 3-6 weeks, and it will heal on its
own. If adequate treatment is not administered, the infection progresses
to the secondary stage.
Secondary Stage
The second stage starts when one or more areas of the skin break into a
rash that usually does not itch. Rashes can appear as the chancre is
fading or can be delayed for weeks. The rash often appears as rough, red
or reddish brown spots both on the palms of the hands and on the bottoms
of the feet. The rash also may also appear on other parts of the body
with different characteristics, some of which resemble other diseases.
Sometimes the rashes are so faint that they are not noticed. Even
without treatment, rashes clear up on their own. In addition to rashes,
second-stage symptoms can include fever, swollen lymph glands, sore
throat, patchy hair loss, headaches, weight loss, muscle aches, and
tiredness. A person can easily pass the disease to sex partners when
primary or secondary stage signs or symptoms are present.
Late Syphilis
The latent (hidden) stage of syphilis begins when the secondary symptoms
disappear. Without treatment, the infected person still has syphilis
even though there are no signs or symptoms. It remains in the body, and
it may begin to damage the internal organs, including the brain, nerves,
eyes, heart, blood vessels, liver, bones, and joints. This internal
damage may show up many years later in the late or tertiary stage of
syphilis. Late stage signs and symptoms include not being able to
coordinate muscle movements, paralysis, numbness, gradual blindness and
dementia. This damage may be serious enough to cause death.
If the disease has not
been effectively treated, bacteria can continue to invade the body, and there
will be a relapse. In this phase, there is a widespread infection that infects
the internal organs, bones, the heart, and the brain. Approximately 30,000 cases
of syphilis in adults are reported each year in the United States. Congenital
syphilis occurs in 1:10,000 live births. Transplacental (from mother to fetus)
transmission of syphilis can result in stillbirth. The risk of transmission to
the fetus in untreated primary or secondary syphilis is approximately 100%.
A blood test can determine
whether someone has syphilis. Shortly after infection occurs, the body produces
syphilis antibodies that can be detected by an accurate, safe and inexpensive
blood test. A low level of antibodies will stay in the blood for months or years
even after the disease has been successfully treated. Because untreated syphilis
in a pregnant woman can infect and possibly kill her developing baby, every
pregnant woman should have a blood test for syphilis
Treatment is usually 100%
effective and results in a cure with simple antibiotics from your neighborhood
doctor.
Treponema Pallidum particle Agglutination Assay (TPPA)
The Treponema pallidum particle agglutination assay
(TPPA) is used to confirm a syphilis infection after screening test results
(RPR) indicate syphilis. This test detects antibodies to the bacteria
that cause syphilis and can be used to detect syphilis in all stages, except
during the first 3 to 4 weeks. This test is not done on spinal fluid.
many of the
signs and symptoms are indistinguishable from those of other diseases.
always
treatable but curable only if diagnosed early
sores also
can occur on the lips and in the mouth.
if adequate
treatment is not administered, the infection progresses to the secondary
stage.
approximately 30,000 cases of syphilis in adults are reported each year in
the United States.
the risk of
transmission to the fetus in untreated primary or secondary syphilis is
approximately 100%.
treatment
is usually 100% effective and results in a cure with simple antibiotics from
your neighborhood doctor.
What is
syphilis?
Syphilis is
a complex sexually transmitted disease (STD) caused by the bacterium
Treponema pallidum. It has often been called "the great imitator"
because so many of the signs and symptoms are indistinguishable from those
of other diseases.
How is
syphilis spread?
Syphilis is
passed from person to person through direct contact with a syphilis sore.
Sores occur mainly on the external genitals, vagina, anus, or in the rectum.
Sores also can occur on the lips and in the mouth. Transmission of the
organism occurs during vaginal, anal, or oral sex. Pregnant women with the
disease can pass it to the babies they are carrying. Syphilis cannot
be spread by toilet seats, door knobs, swimming pools, hot tubs, bath tubs,
shared clothing, or eating utensils.
Signs and symptoms in adults?
Primary
Stage
The time between infection with syphilis and the start of the first
symptom can range from 10-90 days (average 21 days). The primary stage of
syphilis is usually marked by the appearance of a single sore (called a
chancre), but there may be multiple sores. The chancre is usually firm,
round, small, and painless. It appears at the spot where syphilis entered
the body. The chancre lasts 3-6 weeks, and it will heal on its own. If
adequate treatment is not administered, the infection progresses to the
secondary stage.
Secondary Stage
The second stage starts when one or more areas of the skin break into a
rash that usually does not itch. Rashes can appear as the chancre is
fading or can be delayed for weeks. The rash often appears as rough, red
or reddish brown spots both on the palms of the hands and on the bottoms
of the feet. The rash also may also appear on other parts of the body with
different characteristics, some of which resemble other diseases.
Sometimes the rashes are so faint that they are not noticed. Even without
treatment, rashes clear up on their own. In addition to rashes,
second-stage symptoms can include fever, swollen lymph glands, sore
throat, patchy hair loss, headaches, weight loss, muscle aches, and
tiredness. A person can easily pass the disease to sex partners when
primary or secondary stage signs or symptoms are present.
Late
Syphilis
The latent (hidden) stage of syphilis begins when the secondary symptoms
disappear. Without treatment, the infected person still has syphilis even
though there are no signs or symptoms. It remains in the body, and it may
begin to damage the internal organs, including the brain, nerves, eyes,
heart, blood vessels, liver, bones, and joints. This internal damage may
show up many years later in the late or tertiary stage of syphilis. Late
stage signs and symptoms include not being able to coordinate muscle
movements, paralysis, numbness, gradual blindness and dementia. This
damage may be serious enough to cause death.
If the disease has not been effectively treated, bacteria can continue to
invade the body, and there will be a relapse. In this phase, there is a
widespread infection that infects the internal organs, bones, the heart, and the
brain. Approximately 30,000 cases of syphilis in adults are reported each year
in the United States. Congenital syphilis occurs in 1:10,000 live births.
Transplacental (from mother to fetus) transmission of syphilis can result in
stillbirth. The risk of transmission to the fetus in untreated primary or
secondary syphilis is approximately 100%.
A blood test can determine
whether someone has syphilis. Shortly after infection occurs, the body produces
syphilis antibodies that can be detected by an accurate, safe and inexpensive
blood test. A low level of antibodies will stay in the blood for months or years
even after the disease has been successfully treated. Because untreated syphilis
in a pregnant woman can infect and possibly kill her developing baby, every
pregnant woman should have a blood test for syphilis
Treatment is usually 100% effective and results in a cure with simple
antibiotics from your neighborhood doctor.
STDWeB provides only health screening services. Tests are provided only for
personal information and/or risk identification purposes. STDWeB does not
diagnose or treat medical conditions. STDWeB screenings do not take the
place of a physician care. Transactions with STDWeB are confidential and
will not be shared with third parties. Tests with "positive" or "indeterminate"
result may require confirmatory testing and may involve additional charges.